Gérard Lina Selected Research

Panton-Valentine leukocidin

1/2014	Kineret®/IL-1ra blocks the IL-1/IL-8 inflammatory cascade during recombinant Panton Valentine Leukocidin-triggered pneumonia but not during S. aureus infection.
8/2013	Severe leukopenia in Staphylococcus aureus-necrotizing, community-acquired pneumonia: risk factors and impact on survival.
5/2013	The staphylococcal toxin Panton-Valentine Leukocidin targets human C5a receptors.
12/2012	Ceftobiprole efficacy in vitro against Panton-Valentine leukocidin production and in vivo against community-associated methicillin-resistant Staphylococcus aureus osteomyelitis in rabbits.
1/2011	Panton-Valentine leukocidin-positive Staphylococcus aureus strains are associated with follicular skin infections.
1/2009	Primary skin abscesses are mainly caused by Panton-Valentine leukocidin-positive Staphylococcus aureus strains.
10/2008	Association of necrotizing pneumonia with Panton-Valentine leukocidin-producing Staphylococcus aureus, regardless of methicillin resistance.
11/2007	Pediatric bone and joint infections caused by Panton-Valentine leukocidin-positive Staphylococcus aureus.
9/2006	Severe osteoarticular infection associated with Panton-Valentine leukocidin-producing Staphylococcus aureus.
11/2005	Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils.

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Gérard Lina Research Topics

Disease

16	Infections 01/2022 - 11/2003
5	Septic Shock (Toxic Shock Syndrome) 10/2018 - 07/2004
5	Necrotizing Pneumonia 01/2014 - 11/2005
4	Tuberculosis (Tuberculoses) 02/2021 - 04/2014
3	Cystic Fibrosis (Mucoviscidosis) 01/2022 - 01/2012
3	Inflammation (Inflammations) 12/2021 - 07/2012
3	Pneumonia (Pneumonitis) 01/2014 - 08/2005
3	Sepsis (Septicemia) 12/2012 - 12/2006
3	Abscess 01/2012 - 12/2006
2	Nontuberculous Mycobacterium Infections 01/2022 - 01/2022
2	Bacteremia 12/2015 - 01/2012
2	Lung Injury 01/2014 - 07/2012
2	Wounds and Injuries (Trauma) 03/2012 - 12/2008
2	Ulcer 03/2012 - 12/2008
2	Diabetic Foot 03/2012 - 12/2008
1	Diabetic Nephropathies (Diabetic Nephropathy) 10/2021
1	Diabetes Mellitus 10/2021
1	Urinary Tract Infections (Urinary Tract Infection) 10/2021
1	Chronic Kidney Failure (Chronic Renal Failure) 10/2021
1	Neoplasms (Cancer) 10/2021
1	Legionnaires' Disease (Legionnaire's Disease) 09/2020
1	Lung Diseases (Lung Disease) 12/2018
1	Allergic Bronchopulmonary Aspergillosis 09/2017
1	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 12/2015
1	Alzheimer Disease (Alzheimer's Disease) 04/2013
1	Central Nervous System Infections (Central Nervous System Infection) 04/2013
1	Porcine Reproductive and Respiratory Syndrome (PRRS) 04/2013
1	Osteomyelitis 12/2012
1	Body Weight (Weight, Body) 12/2012
1	Endocarditis 01/2012
1	Endophthalmitis (Ophthalmia) 12/2009
1	Soft Tissue Infections 01/2009
1	Foot Ulcer 12/2008
1	Blister (Bulla) 10/2008
1	Osteoarthritis 09/2006
1	Thrombosis (Thrombus) 09/2006
1	Mastitis 11/2002

Drug/Important Bio-Agent (IBA)

11	Panton-Valentine leukocidinIBA 01/2014 - 08/2005
4	Anti-Bacterial Agents (Antibiotics)IBA 04/2014 - 09/2006
3	Rifampin (Rifampicin)FDA LinkGeneric 02/2021 - 12/2012
3	Pharmaceutical PreparationsIBA 04/2020 - 12/2015
3	Leukocidins (Leukocidin)IBA 10/2018 - 08/2015
3	InflammasomesIBA 01/2014 - 07/2012
2	Virulence Factors (Pathogenicity Factors)IBA 12/2021 - 01/2012
2	Isoniazid (Ftivazide)FDA LinkGeneric 02/2021 - 01/2018
2	Linezolid (Zyvox)FDA Link 12/2015 - 12/2015
2	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 01/2014 - 07/2012
2	RNA (Ribonucleic Acid)IBA 01/2012 - 11/2002
1	Immunoglobulin A (IgA)IBA 01/2022
1	Biomarkers (Surrogate Marker)IBA 01/2022
1	staphylococcal delta toxinIBA 12/2021
1	AntigensIBA 09/2020
1	Clindamycin (Cleocin)FDA LinkGeneric 10/2018
1	Interleukin-8B ReceptorsIBA 01/2018
1	Staphylococcal enterotoxin FIBA 01/2018
1	Itraconazole (Sporanox)FDA LinkGeneric 09/2017
1	Adrenal Cortex Hormones (Corticosteroids)IBA 09/2017
1	CoagulaseIBA 12/2015
1	1,2- diarachidonoyl- glycero- 3- phosphocholineIBA 12/2015
1	Methicillin (Metin)FDA Link 12/2015
1	Interleukin-1 (Interleukin 1)IBA 01/2014
1	Interleukin-8 (Interleukin 8)IBA 01/2014
1	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2014
1	CytokinesIBA 04/2013
1	FlagellinIBA 04/2013
1	Interleukin-18 (Interleukin 18)IBA 04/2013
1	Pattern Recognition ReceptorsIBA 04/2013
1	ceftobiproleIBA 12/2012
1	Vancomycin FDA LinkGeneric 12/2012
1	Peptides (Polypeptides)IBA 07/2012
1	DNA (Deoxyribonucleic Acid)IBA 03/2012
1	OligonucleotidesIBA 03/2012
1	Indicators and Reagents (Reagents)IBA 11/2008
1	leukotoxinIBA 12/2006
1	Enterotoxins (Enterotoxin)IBA 07/2004
1	SuperantigensIBA 07/2004
1	Interferon-gamma (Interferon, gamma)IBA 11/2003

Therapy/Procedure

4	Therapeutics 12/2018 - 11/2003
1	Lung Transplantation 01/2022
1	Stents 10/2021
1	Menstrual Hygiene Products (Menstrual Pad) 01/2018
1	Drug Therapy (Chemotherapy) 12/2015
1	Kidney Transplantation 12/2011
1	Vitrectomy 12/2009
1	Filtering Surgery 10/2008
1	Resuscitation 08/2005
1	Hip Prosthesis 11/2003